Institute for Systems Biology
The goal of the Moritz Lab is to bring together scientific expertise from diverse areas such as biology, chemistry, proteomics, physics, bioinformatics, and statistics, to enhance and develop innovative proteomic technologies and apply them to biological questions relevant to human health and wellbeing.
The use of blood and tissue samples to look for biomarkers that indicate the presence or stage of a disease presents many challenges. For example, proteins in the blood have an extraordinary range of abundances, with common proteins like albumin billions of times more abundant than trace proteins like cytokines.
Every year, the Moritz Lab holds the Cascadia Proteomics Symposium. Last year’s symposium was held on July 22 & 23, 2024 at ISB in Seattle.
Like the draft “shotgun” Human Genome Project of the Human Genome Organization (HUGO), the HPP has now reached a significant decadal milestone of more than 90 percent completion of the Human Proteome that is referred to as the human proteome “parts list.”
ISB researchers and their collaborators are using systems biology approaches to learn how the malaria parasite is able to transfer to humans via the bite of an infected mosquito. The information they have uncovered may help identify new ways to prevent people from contracting the deadly disease.
Microsoft Research recently deployed a video crew to come to ISB to speak with our researchers about proteomics and sharing peptide data. A story featuring the video was published on the Microsoft Research blog.