Built and optimized for large-scale quantitative mass spectrometry, the TripleTOF 6600+ System offers sensitive and robust quantitation using dedicated low flow source technology. Redesigned TOF entrance optics, along with Analyst TF Software 1.8 software, deliver optimized ion beam control, detector tuning, and scheduled ionization to decrease the risk of downtime over long-term usage. Combined with the characteristically fast scanning capability, SWATH Acquisition, and the ultimate approach for data-independent digital archiving of samples, the instrument performs high-quality quantitative data for many applications.