Senior Software Engineer
moritz.isbscience.org/bio/tami-leppert/
Tami Leppert joined the proteomic research group at ISB in 2019. She is working on the PeptideAtlas project, cateloguing Arabidopsis thaliana peptides. Prior to working at ISB, she worked at Lawrence Livermore National Labs as a collaborator on hair identification for forensics uses. There she developed protein databases with variants for the use of matching genotypic data variants for individual identification. For most of her career, she worked at the University of Utah Human Genetics Department as an analyst and programmer developing software tools to analyze Three Generation UGRP-CEPH pedigrees as well as pedigrees with genetic disease phenotypes. She also helped in the development of algorithms for the genetic analysis LINKAGE package with Dr. Jean-Marc Lalouel and Dr. Mark Lathrop. She has designed and developed programs to analyze SNP data looking for shared regions, haplotypes and chromosomal breakpoints. She developed an extensive Oracle database containing genetic, familial and medical information about individuals in large extended pedigrees to expedite researchers in complex gene discovery. Her programs that draw complex and large pedigrees (>5,000 individuals) are still being used at the Huntsman Cancer Institute in Salt Lake City. For a large nationwide NIH collaborative study on hypertension genes, she was the software designer for and led a team of programmers to develop an automated genotyping collection system from digitized flourescent images. The system entailed image capture, manipulation, analysis, and database storage for a large volume of digitized images.
Experienced computer professional, genomic data, proteomic data, database design and implementation.
Bachelor of Science – Utah State University
Major: Computer Science with Engineering emphasis
Minor: Mathematics
Glendon J. Parker, Tami Leppert, Deon S. Anex, Jonathan K. Hilmer, Nori Matsunami, Lisa Baird, Jeffery Stevens, Krishna Paraswar, Blythe P. Durbin-Johnson, David M. Rocke, Chad Nelson, Daniel J. Fairbanks, Andrew S. Wilson, Robert H. Rice, Scott R. Woodward, Brian Bothner, Bradley R. Hart, Mark Leppert; Demonstration of Protein-Based Human Identification Using the Hair Shaft Proteome. PLoS one. 2016 Sep 7; 11(9):e0160653.
Matsunami N, Hensel CH, Baird L, Stevens J, Otterud B, Leppert T, Varvil T, Hadley D, Glessner JT, Pellegrino R, Kim C, Thomas K, Wang F, Otieno FG, Ho K, Christensen GB, Li D, Prekeris R, Lambert CG, Hakonarson H, Leppert MF. Identification of rare DNA sequence variants in high-risk autism families and their prevalence in a large case/control population. Mol Autism. 2014 Jan 27;5(1):5.
Matsunami N, Hadley D, Hensel CH, Christensen GB, Kim C, Frackelton E, Thomas K, da Silva RP, Stevens J, Baird L, Otterud B, Ho K, Varvil T, Leppert T, Lambert CG, Leppert M, Hakonarson H. Identification of rare recurrent copy number variants in high-risk autism families and their prevalence in a large ASD population. PLoS One. 2013;8(1):e52239.
Arrington CB, Bleyl SB, Matsunami N, Bowles NE, Leppert TI, Demarest BL, Osborne K, Yoder BA, Byrne JL, Schiffman JD, Null DM, DiGeronimo R, Rollins M, Faix R, Comstock J, Camp NJ, Leppert MF, Yost HJ, Brunelli L. A family-based paradigm to identify candidate chromosomal regions for isolated congenital diaphragmatic hernia. Am J Med Genet A. 2012 Dec;158A(12):3137-47.
Dennis Drayna, Hilary Coon, Un-Kyung Kim, Tami Elsner, Kevin Cromer, Brith Otterud, Lisa Baird, Andy P. Peiffer, Mark Leppert; Genetic analysis of a complex trait in the Utah Genetic Reference Project: a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p (Citations: 28) Journal: Human Genetics – HUM GENET , vol. 112, no. 5, pp. 567-572, 2003
Alka Malhotra, Andy P. Peiffer, Darin T. Ryujin, Tami Elsner, Richard E. Kanner, Mark F. Leppert, Sandra J. Hasstedt Further Evidence for the Role of Genes on Chromosome 2 and Chromosome 5 in the Inheritance of Pulmonary Function. Am J Respir Crit Care Med. 2003 Sep;168(5):556-61.
Elsner TI; Albertsen H; Gerken SC; Cartwright P; White RL; Breakpoint analysis: precise localization of genetic markers by means of nonstatistical computation using relatively few genotypes. Am. J. Hum. Genet. 1995; 56:500-507.
Gerken SC; Albertsen H; Elsner T; Ballard L; Holik P; Lawrence E; Moore M; et al. A strategy for constructing high resolution genetic maps of the human genome: a genetic map of chromosome 17p, ordered with meiotic breakpoint mapping panels. Am J Hum Genet, 1995; 56:484-499.
Gerken S; Leppert M; O’Connell P; Cavenee W; James CD; Ballard L; Stauffer D; Elsner T; Plaetke R; Lalouel JM; et al. A genetic linkage map with 29 loci spanning human chromo some 13q. Genomics (GEN), 1993 May; 16 (2): 515-9.
Melis R; Bradley P; Elsner T; Robertson M; Lawrence E; Gerken S; Albertsen H; White R. Polymorphic SSR (simple-sequence-repeat) markers for chromosome 20. Genomics (GEN), 1993 Apr; 16 (1): 56-62.
O’Connell P; Lathrop GM; Law M; Leppert M; Nakamura Y; Hoff M; Kumlin E; Thomas W; Elsner T; Ballard L; et al. A primary genetic linkage map for human chromosome 12. Genomics (GEN), 1987 Sep; 1 (1): 93-102.
Dracopoli NC; O’Connell P; Elsner TI; Lalouel JM; White RL; Buetow KH; Nishimura DY; Murray JC; Helms C; Mishra SK; et al. The CEPH consortium linkage map of human chromosome 1. Genomics (GEN), 1991 Apr; 9 (4): 686-700.
