Like the draft “shotgun” Human Genome Project of the Human Genome Organization (HUGO), the HPP has now reached a significant decadal milestone of more than 90 percent completion of the Human Proteome that is referred to as the human proteome “parts list.”
In the cellular process of differentiation, information about the concentrations of an important class of proteins residing in a cell’s nucleus has been lacking, a missing link needed for scientists to fully understand how the process works. ISB researchers have quantified this important class of proteins that play a key role in the formation of red blood cells.
ISB researchers and their collaborators are using systems biology approaches to learn how the malaria parasite is able to transfer to humans via the bite of an infected mosquito. The information they have uncovered may help identify new ways to prevent people from contracting the deadly disease.
Chemical & Engineering News highlighted ISB’s recent publication (Identifying Organ-Specific Blood Biomarkers for Acute Liver Injury) in the Journal of Proteome Research. “For many years, clinicians have relied on assays for two enzymes, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), to detect liver injury. These biomarkers have limitations, says Leroy Hood of the Institute for Systems Biology, such as a short half-life and a tendency to underreport damage in certain…