Like the draft “shotgun” Human Genome Project of the Human Genome Organization (HUGO), the HPP has now reached a significant decadal milestone of more than 90 percent completion of the Human Proteome that is referred to as the human proteome “parts list.”
In the cellular process of differentiation, information about the concentrations of an important class of proteins residing in a cell’s nucleus has been lacking, a missing link needed for scientists to fully understand how the process works. ISB researchers have quantified this important class of proteins that play a key role in the formation of red blood cells.
ISB researchers and their collaborators are using systems biology approaches to learn how the malaria parasite is able to transfer to humans via the bite of an infected mosquito. The information they have uncovered may help identify new ways to prevent people from contracting the deadly disease.
Since national surveillance of Lyme Disease started in 1982, the number of cases reported annually has increased nearly 25-fold. Lyme Disease specialist Dr. Susan Marra recently produced a video, “Ending Lyme,” about the latest in Lyme research that features ISB Drs. Jim Heath, Lee Hood, Rob Moritz, Naeha Subramanian and Nathan Price.
ISB’s Moritz Lab has received research funding totaling nearly $525,000 from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health to develop “novel peptide based biomarkers for Lyme disease diagnostics.”
Microsoft Research recently deployed a video crew to come to ISB to speak with our researchers about proteomics and sharing peptide data. A story featuring the video was published on the Microsoft Research blog.
ISB, Integrated Diagnostics and Sera Prognostics just announced a paper entitled, “The building blocks of successful translation of proteomics to the clinic,” by Leroy Hood and colleagues published online in Current Opinion in Biotechnology.
A new report in PLOS Neglected Tropical Diseases describes the results of an international collaboration led by researchers at ISB and Seattle’s Center for Infectious Disease Research (CIDResearch). We used mass spectrometry-based proteomics to identify nearly 2,000 proteins present in Plasmodium vivax parasites, one of the Plasmodium species that cause the disease malaria in humans. The work was done on parasites dissected from mosquito salivary glands, parasites that were in…
A team from the Moritz Lab at ISB headed to Delhi, India, to host a workshop on the Trans-Proteomic Pipeline (TPP). @ISBUSA Luis Mendoza and Dave Campbell open up the TPP course in Delhi India today to teach proteomics from the Moritz Lab. Welcome students pic.twitter.com/01hkteGfrr — rmoritz (@r_l_moritz) December 9, 2016 Many thanks from the Moritz lab @ISBUSA to the TPP Delhi Course participants and thanks to Brijesh Pandey…
Congratulations to Dr. Michael Hoopmann, of the Moritz Lab, who has been promoted to Senior Research Scientist. His research is focused on proteomics technology and methods development, having been trained in both instrumentation and software data analysis, with particular focus on high-resolution mass spectrometry. His current interests are in the development of advanced algorithms for discovery-based proteomics. He is the developer of the Kojak algorithm, a versatile, open-source software application…
Chemical & Engineering News highlighted ISB’s recent publication (Identifying Organ-Specific Blood Biomarkers for Acute Liver Injury) in the Journal of Proteome Research. “For many years, clinicians have relied on assays for two enzymes, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), to detect liver injury. These biomarkers have limitations, says Leroy Hood of the Institute for Systems Biology, such as a short half-life and a tendency to underreport damage in certain…
PRESS RELEASE Total Funding Has Reached $6.1 Million ISB Researchers Have Discovered Potential Biomarkers and Successfully Reproduced the Borrelia Bacteria in the Lab SEATTLE – June 1, 2016 – Institute for Systems Biology (ISB) has received a transformational, multi-year pledge from the Steven & Alexandra Cohen Foundation to support the Wilke Cohen Lyme Disease Project. In addition to an initial $3.1 million in funding from Jeff and Liesl Wilke, Jeff…
Photo by Hsiao-Ching Chou Dr. Kristian Swearingen is a research scientist in the Moritz Lab at ISB. He and his collaborators just published a paper in PLOS Pathogens that describes potential new targets for malaria vaccines. Read his article about the research. Asked about the challenge of having to dissect thousands of mosquitoes, he commented: When we started this project, my collaborators collected all the parasites and I focused on…
Ötzi the Iceman: In a study published in the Jan. 8, 2016, issue of the journal Science, researchers from the Moritz group at ISB collaborated with a worldwide consortia headed by Prof. Albert Zink and Dr. Frank Maixner, of the Institute for Mummies and the Iceman at the European Academy of Bozen/Bolzano (EURAC) in Italy; Prof. Thomas Rattei, of the University of Vienna; and Dr. Rudi Grimm, of University of…
ISB’s Moritz Group, which specializes in proteomics, collaborated on research related to study pathogens from the stomach content and microbiome of Ötzi, a glacier mummy from the European Copper Age. The results were published in Science. Read the article here. Institute for Systems Biology collaborates with researchers worldwide to study pathogens in the stomach content and microbiome of the 5300 year old European Copper Age glacier mummy “Ötzi” and discovers…
A message from… By Dr. Lee Hood President, Institute for Systems Biology As most of you know, Rob Moritz has recently been promoted to full professor at ISB—a promotion long overdue. As long as I have known Rob, he has always done things without fuss, but this time we will toast him for his achievement. He also wants to credit the efforts of his group for their significant contributions that…
Study Utilizes Systems Approaches to Develop Diagnostics and Deeper Understanding of Chronic Lyme PRESS RELEASE, SEATTLE, March 26, 2015 – Institute for Systems Biology (ISB) has received $2.13 million in transformational gifts from Jeff and Liesl Wilke; Jeff and MacKenzie Bezos; and the Bay Area Lyme Foundation to tackle chronic Lyme disease, a highly complex and often misdiagnosed disease that can be debilitating for those who do not respond to…
3 Bullets SWATH mass spectrometry, an emerging protein analysis technique being pioneered by ISB researchers, provides a digital fingerprint of all accessible proteins in a sample. The data generated by the SWATH technique are highly complex and require sophisticated computational tools in order to extract identities from a sea of data. ISB researchers have released a free, open source program that allows users to confidently identify and quantify proteins analyzed…
